SAR131675 (b)

Research use only, not for human use.

SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (IC50: 45 nmol/L) in HEK cells, respectively.

SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is the first highly specific VEGFR-3-TK inhibitor described to date, displaying significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.

SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.

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SAR131675 | SAR 131675 | SAR-131675

Others

Other Targets

VEGFR3

Cancer

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1092539-44-0

358.16

C18H22N4O4

>98% (HPLC)

——

CCn1c(c(c(=O)c2c1nc(cc2)C#CC(C)(COC)O)C(=O)NC)N

2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

(-20℃)

With Ice Pack

≥ 2 years